Exploring the Chemical Composition and Cardioprotective Properties of Plumeria obtusa Using Advanced LC-MS/MS and Computational Methods in a Rabbit Model of AdriamycinInduced Myocardial Injury

Abstract

Using cutting-edge analytical and computational methods, this study explores Plumeria obtusa's chemical makeup and pharmacological properties. A plant with considerable traditional restorative effects, Plumeria obtusa, was examined using Fluid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) to determine its bioactive compounds. The analysis revealed the existence of many compounds including alkaloids, phenols, tannins, anthraquinones, saponins, and coumarins. The plant's true capacity as a cardioprotective specialist is additionally investigated in this study by assessing what it means for myocardial harm caused by Adriamycin (ADR) in a bunny model. The findings of the study show that Plumeria obtusa extract significantly lowers levels of cardiohepatic indicators (ALT, CRP, ALP, and AST) and cardiac biomarkers (troponin, CK-MB, LDH). There is also a favorable link between the protective impact and extract dosage. These results demonstrate the therapeutic potential of Plumeria obtusa in protecting the cardiovascular system and emphasize the need for more research to maximize its application and comprehend its mechanisms of action.