Synthetic Approaches of Pyrazole Derivatives on Various Pharmacological Activity: A Review

Abstract

Pyrazoles are an interesting heterocyclic class of compounds that have attracted extensive attention in medicinal chemistry as a consequence of their wide range of pharmacological activities. The compounds possess a wide variety of biological properties such as antibacterial, antifungal, anticancer, antidepressant, anti-inflammatory, and antiviral activity. Pyrazoles can be synthesized through several different routes, for example, cyclocondensation reactions between hydrazine derivatives and carbonyl systems, dipolar cycloadditions between alkynes or olefins and 1,3-dipolar compounds, and multicomponent reactions that allow the synthesis of pyrazoles in one step. Pyrazole derivatives have exhibited promise in a number of therapeutic applications, such as antimicrobial, anti-inflammatory, and anticancer activities, and thus are promising compounds for further research and development in the treatment of diseases. In general, the versatility and pharmacological relevance of pyrazoles highlight their significance in the advancement of medicinal chemistry research.