Formulation Development and Evaluation of Tablet Dosage Form for Quick and Protracted Relief in Gastritis and Allied Gastric Disorders

Abstract

Objective: The object of the current study was to evaluate the tablet's uniqueness in tablet composition with the belief that it would provide both immediate and long-term relief from gastritis and related stomach problems. Method: It was intended to match the batch composition formulae for the core tablets to the potential drug-excipient interaction between Esomeprazole Magnesium and the formulation constituents/excipients of the core and outer tablet. The outer tablets and core tablets were squeezed using a 6.5 mm die punch (concave) set. (without core tablet) were crushed with a 14 mm concave die punch that was adjusted to the ideal compression load and speed. Three batches of tablets were purposed and compressed based on the performance results of the core and outside tablet batches. These batches were then exposed to in vitro release kinetics during the evaluation of the post compression parameters. To predict how the environment would affect the final formulation's quality and to make sure that no changes had been made to the formulation during the manufacturing process, short-term accelerated stability testing of the various tablet batches in tablet formulations was carried out. things can have an adverse effect on its stability. Result and conclusion: With a crushing strength of 3.57, the batch which included sodium starch glycolate as a disintegrant and polyethylene glycol as a binder was the best of all the batches (CT-1 to CT-9), according to the post-compression characteristics of the core tablets. ± 0.115 kg/cm2, a disintegration time of 52.66 ± 0.57 s, a Friability of 0.188 ± 0.002 (percent loss), and a drug content of 100.31 ± 0.32. Out of all batches (OT-1 to OT-9), the OT-2 batch, which contained microcrystalline cellulose as the disintegrant, outperformed the others according to the post-compression parameters of the outer tablet. Its crushing strength was 5.55 ± 0.132 kg/cm2, its friability was 0.098 ± 0.004 (percent loss), and its disintegration time was 161.33 ± 0.57 seconds.