Development and Optimization of Acyl Chitosan-Based SNEDDS for Enhanced Oral Bioavailability of Lipophilic Drugs

Abstract

The study aimed to develop and optimize acyl chitosan-based Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) to enhance the oral bioavailability of lipophilic drugs. SNEDDS formulations were optimized using Response Surface Methodology (RSM), considering parameters like oil-to-surfactant ratio, drug loading efficiency, droplet size, and stability. The optimized formulation demonstrated improved solubility, stability, and enhanced self-emulsification. In vivo pharmacokinetic evaluations revealed significant improvements in bioavailability, with a 200% increase in relative bioavailability compared to conventional SNEDDS. The optimized formulation achieved faster drug absorption, higher plasma concentrations, and extended therapeutic effects, confirming the potential of acyl chitosan-based SNEDDS for improving the oral bioavailability of poorly soluble lipophilic drugs. The results underscore the advantages of this formulation approach for developing more effective and stable drug delivery systems, offering substantial implications for the pharmaceutical industry.