Formulation and Characterization of SIPI-Based Implants for Long-Term Drug Release in Chronic Disease Management

Authors

  • Nisha, Shereen Khan, Kpurna Chander, Uriti Sri Venkatesh*

Keywords:

Stimuli-Responsive Injectable Polymeric Implants (SIPI), Chronic Disease Management, Sustained Drug Release, Biodegradable Polymers, Drug Delivery System, Controlled Release, Polymer Characterization, In-vitro Drug Release.

Abstract

This study focuses on the formulation and characterization of Stimuli-Responsive Injectable Polymeric Implants (SIPI) for long-term drug release in chronic disease management. Chronic conditions such as diabetes, cardiovascular disorders, and neurodegenerative diseases require continuous therapeutic delivery, which traditional methods often fail to sustain due to poor compliance and fluctuating drug levels. SIPI systems offer an innovative solution by utilizing biodegradable polymers that respond to physiological stimuli—such as pH and temperature—to modulate drug release. Four formulations were developed using PLGA, PCL, Chitosan, and a PLGA-Chitosan blend. These were evaluated for physicochemical properties, thermal stability, surface morphology, biodegradation, and drug release kinetics. The PLGA-Chitosan formulation (F4) exhibited optimal performance, balancing mechanical strength, degradation rate, and controlled drug release. In-vitro studies confirmed biphasic release profiles and diffusion-controlled mechanisms as per Korsmeyer-Peppas and Higuchi models. Analytical techniques including FTIR, DSC, SEM, and HPLC validated structural compatibility and performance stability. Overall, SIPI-based implants demonstrate promising potential for site-specific, long-term drug delivery in chronic disease therapy. The results support further in-vivo investigations and clinical development of smart, patient-compliant drug delivery platforms designed to enhance therapeutic efficacy and improve quality of life in long-term treatment scenarios.

Author Biography

  • Nisha, Shereen Khan, Kpurna Chander, Uriti Sri Venkatesh*

    1Associate Professor, School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab (147301)

    2Ph.D. Scholar, Rabindranath Tagore University

    3Assistant Professor, MNR College of Pharmacy, Sangareddy, Telangana, India-502294

    4Associate Professor, Department of Pharmacology, Sri Sivani College of Pharmacy, Affiliated to JNTUGV Chilakapalem Jn Etcherla Mandal Srikakulam Dist Andhra Pradesh

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Published

2025-04-04

How to Cite

Formulation and Characterization of SIPI-Based Implants for Long-Term Drug Release in Chronic Disease Management. (2025). Current Pharmaceutical Letters And Reviews, 2(1), 28-36. https://cplr.in/index.php/files/article/view/122

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