Strategic Design and Synthesis of Betulinic Acid Derivatives for Targeted Cancer Treatment

Abstract

The purpose of this research is to investigate the strategic design and synthesis of betulinic acid derivatives as potential targeted medicines for the treatment of cancer. Our evaluation of the bioactivity, selectivity, and inhibitory potency of these compounds against cancer cell lines was carried out by means of exhaustive in vitro experiments. As a result of our research, we have discovered that the effectiveness of betulinic acid derivatives varies, with Derivative 2 demonstrating the most potential. Additionally, it displayed better inhibition of cell proliferation, notably in Cancer Cell Line A and B. It was able to dramatically diminish the viability of cancer cells. Furthermore, Derivative 2 maintained a reasonably high level of vitality in normal cell lines, which might be interpreted as an indication of its promising selectivity and reduced toxicity. The significance of these findings lies in the fact that betulinic acid derivatives, particularly Derivative 2, have the potential to serve as excellent candidates for targeted cancer therapy.